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Loading Dosing Examples: PCA (Maintenance) Dose The PCA dose of opioid is the amount of drug the PCA pump will deliver when the demand button is pressed.

The size of the maintenance (PCA) dose is the primary determinant of the effectiveness of PCA.

Trazodone was a more effective and less-costly than quetiapine as an alternative sleeping pill.

Trazodone prolonged sleep time and decreased the number of nighttime awakenings better than quetiapine.

Therefore, titration of the maintenance (PCA) dose, based on objective caregiver assessment of pain, is the cornerstone of PCA therapy.

Patient weight is a useful on which to base the PCA dose, even though the correlation between analgesic requirement and weight is poor.

Trazodone's hypnotic properties are due to its antihistaminergic effects at the histamine-1 receptor, alpha 1-adrenergic receptor antagonism, and serotonin 5-HT2 receptor antagonism.

During the first week, both trazodone and zolpidem were similar in improving sleep latency, total sleep time and sleep quality, and decreasing wakefulness after sleep onset.

It causes adrenoreceptor subsensitivity, and induces significant changes in 5-HT presynaptic receptor adrenoreceptors.

This agent also blocks histamine (H1) and alpha1-adrenergic receptors.

Many studies have demonstrated a five fold variability in the quantity of intravenous opioid required to produce equivalent analgesia after surgery.

The loading dose should be repeated every 5 -10 minutes (5 minutes for fentanyl) so that the effect of the dose is felt before the next dose is administered.

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Currently, trazodone is the second most commonly prescribed treatment for insomnia.

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